Journal
LEUKEMIA RESEARCH
Volume 33, Issue 10, Pages 1352-1356Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.leukres.2009.01.009
Keywords
Hodgkin lymphoma; IL-10; Polymorphism; Plasma level
Categories
Funding
- Fondazione Roma - Progetto Cellule Staminali
- Associazione Italiana per la Ricerca sul Cancro Funding Source: Custom
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We studied plasma levels of IL-10 and five single nucleotide polymorphisms in the interleukin-10 (1110) gene promoter in patients with Hodgkin lymphoma (HL) to address potential genotype-phenotype correlations. Patients with elevated IL-10 levels were more likely to have advanced stage disease and inferior event-free survival. Homozygous carriers of the variant alleles at position -592 (AA) and -1082 (GG) of the IL-10 promoter had higher IL-10 plasma levels, independent of male gender and advanced stage of disease which also determined increased IL-10 production. This analysis indicates that the genetic background can modulate plasma levels of IL-10, and ultimately prognosis in HL. (c) 2009 Elsevier Ltd. All rights reserved.
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