Journal
LEUKEMIA RESEARCH
Volume 32, Issue 1, Pages 19-24Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.leukres.2007.02.011
Keywords
acute lymphoblastoid leukernia; paediatric patients; methotrexate; MTHFR C677T; TSER 2R/3R; Indonesia
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Genetic variations in the polymorphic tandem repeat sequence of the enhancer region of the thymidylate synthase promoter(TSER), as we] I as in methylenetetrahydrofolate reduclase (MTHFR) C677T polymorphism, influence methotrexate sensitivity. We studied these polymorphisms in children with acute lymphoblastic leukaemia (ALL) and in subjects without malignancy in Indonesia and Holland. The frequencies of 77 and CT genotypes were two-fold higher in Dutch children. The TSER 3R/3R repeat was three-fold more frequent in the Indonesian children, while the 2R/2R repeat was only 1% compared to 21% in the Dutch children. No differences of these polymorphisms were found between ALL cells and normal blood cells, indicating an ethnic rather than leukemic origin. These results may have implications for treatment of Indonesian children with ALL. (c) 2007 Elsevier Ltd. All rights reserved.
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