Journal
LEUKEMIA RESEARCH
Volume 32, Issue 11, Pages 1653-1660Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.leukres.2008.03.038
Keywords
dendritic cells; allogeneic immunotherapy; acute myeloid leukemia
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Funding
- Ministry of Commerce, Industry and Energy, Republic of Korea [RT105-01-01]
- Ministry of Science and Technology, Republic of Korea [SC3290]
- National Research Foundation of Korea [SC3290] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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We investigated the usefulness of allogeneic monocyte-derived dendritic cells (allogeneic mDCs) pulsed with leukemic lysates in acute myeloid leukemia (AML). Allogeneic mDCs showed higher expressions of several molecules (HLA-DR, CD80, CD83 or CD 86), higher production of IL-12 and higher capacity to stimulate allogeneic T cells compared to both leukemic DCs and autologous m DCs. Autologous T cells primed by allogeneic mDCs displayed a larger number of interferon-gamma-secreting cells against leukemic cells than those primed by either leukemic DCs autologous mDCs. These results suggest that monocyte-derived DCs from HLA-matched allogeneic donors can be used as an alternative to generate leukemia-specific cytotoxic T cells and to overcome the limitation of leukemic DCs or autologous mDCs. (C) 2008 Elsevier Ltd. All rights reserved.
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