Journal
LEUKEMIA & LYMPHOMA
Volume 54, Issue 11, Pages 2433-2440Publisher
TAYLOR & FRANCIS LTD
DOI: 10.3109/10428194.2013.780655
Keywords
Immunosuppression; posttransplant lymphoproliferative disorder; PTLD; transplant
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Funding
- K. U. Leuven [GOA/11/010]
- FWO-Vlaanderen [GO81411N]
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Hematopoietic stem cell and solid organ transplant recipients diagnosed with biopsy-confirmed posttransplant lymphoproliferative disorder (PTLD) at our institution from 1989 to 2010 were identified. Patient-, transplant- and disease-related characteristics, prognostic factors and outcome were collected and analyzed. One hundred and forty biopsy-proven cases of PTLD were included. Overall incidence in the transplant population was 2.12%, with heart transplant recipients carrying the highest risk. Most PTLDs were monomorphic (82%), with diffuse large B-cell lymphoma being the most frequent subtype. The majority of cases (70.7%) occurred >1 year posttransplant, and 66% were Epstein-Barr virus positive. Following initial therapy the overall response rate was 68.5%. Three-year relapse-free and overall survivals were 59% and 49%, respectively. At last follow-up, 44% of the patients were alive. Multivariable analysis identified several classical lymphoma-specific poor prognostic factors for the different outcome measures. The value of the International Prognostic Index was confirmed in our analysis.
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