Journal
LEUKEMIA & LYMPHOMA
Volume 54, Issue 8, Pages 1647-1651Publisher
INFORMA HEALTHCARE
DOI: 10.3109/10428194.2012.753449
Keywords
Chronic lymphocytic leukemia; CLL; regression; monoclonal B lymphocytosis; MBL
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Spontaneous remission of chronic lymphocytic leukemia (CLL) is an unusual and poorly characterized event. We performed a search for spontaneous remission in patients with CLL. Cases must have had a pathological diagnosis of CLL with disease duration >6 months. Spontaneous remission was defined as absence of lymphadenopathy or splenomegaly with lymphocyte counts <5 x 10(9)/L for >9 months without therapy. We identified 20 cases and included one additional case from our institution. Fourteen cases (67%) showed remission into monoclonal B lymphocytosis (MBL) and seven (33%) into a normal phenotype. There was no difference in age distribution, lymphocyte count or stage between groups. There was a significant difference in the median duration of CLL prior to remission, 13 years in the MBL versus 3 years in the normal phenotype group (p = 0.03). This difference in the duration of CLL prior to remission could be due to a possible distinct pathophysiology for these events.
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