Journal
LEUKEMIA & LYMPHOMA
Volume 54, Issue 8, Pages 1691-1697Publisher
TAYLOR & FRANCIS LTD
DOI: 10.3109/10428194.2012.753543
Keywords
Second malignancies; radiotherapy; non-Hodgkin lymphoma
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Funding
- Intramural NIH HHS [ZIA CP010170-12] Funding Source: Medline
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Ionizing radiation increases risk for acute leukemia, but less is known about radiation and risk of other hematologic malignancies such as non-Hodgkin lymphoma (NHL). We compared second primary NHL incidence among patients who did and did not receive initial radiotherapy for first primary solid malignancy during 1981-2007 reported in nine Surveillance, Epidemiology, and End Results (SEER) Program population-based cancer registries. We identified 5590 second NHL cases among 1 450 962 1-year cancer survivors. NHL risk was increased after initial radiotherapy for all solid cancers combined (multivariate Poisson regression relative risk [RR]: 1.13, 95% confidence interval [CI]: 1.06-1.20), non-small cell lung cancer (RR: 1.53, 95% CI: 1.08-2.17) and prostate cancer (RR: 1.19, 95% CI: 1.09-1.32). NHL risk increased with longer latency after radiotherapy for non-small cell lung cancer (p(trend) = 0.003) but decreased for prostate cancer (p(trend) = 0.017). There was no clear NHL risk pattern by NHL subtype or age. Our study provides limited evidence that radiotherapy for solid malignancy is associated with increased risk of subsequent NHL.
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