Journal
LEUKEMIA & LYMPHOMA
Volume 52, Issue 8, Pages 1537-1543Publisher
INFORMA HEALTHCARE
DOI: 10.3109/10428194.2011.584253
Keywords
Nanodisks; mantle cell lymphoma; curcumin; cell cycle; apoptosis
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Funding
- Northwestern University Feinberg School of Medicine Department of Medicine
- Meyer Research Fund
- Philip Bligh Research Fund
- National Institutes of Health (NIH) [HL-64159]
- National Heart, Lung and Blood Institute
- National Cancer Institute [1R43CA141904]
- American Heart Association [10PRE3600031]
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Mantle cell lymphoma (MCL) is a pre-germinal center neoplasm characterized by cyclin D1 overexpression resulting from t(11; 14)(q13; q32). Since MCL is incurable with standard lymphoma therapies, new treatment approaches are needed that target specific biologic pathways. In the present study, we investigated a novel drug delivery nanovehicle enriched with the bioactive polyphenol, curcumin (curcumin nanodisks; curcumin-ND). Cells treated with curcumin-ND showed a dose-dependent increase in apoptosis. This was accompanied by enhanced generation of reactive oxygen species (ROS). The antioxidant, N-acetylcysteine, inhibited curcumin-ND induced apoptosis, suggesting that ROS generation plays a role in curcumin action on MCL cells. Curcumin-ND decreased cyclin D1, pAkt, pI kappa B alpha, and Bcl(2) protein. In addition, enhanced FoxO3a and p27 expression as well as caspase-9, -3, and poly(ADP-ribose) polymerase (PARP) cleavage were observed. Curcumin-ND treatment led to enhanced G(1) arrest in two cultured cell models of MCL.
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