Journal
LEUKEMIA & LYMPHOMA
Volume 51, Issue 1, Pages 10-19Publisher
TAYLOR & FRANCIS LTD
DOI: 10.3109/10428190903370346
Keywords
Hematogones; precursor B-cells; lymphoblasts; myelodysplastic syndrome; aplastic anemia; review
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Our knowledge regarding the nature and function of 'hematogones' has evolved considerably, since the initial description more than 70 years ago. Once considered the 'mystery cells' of the bone marrow, major advances in immunology and flow cytometry have enabled us to better characterize these cells and recognize them as physiologic precursors of B-cells. In this review, we describe the morphologic and phenotypic characteristics and clinical relevance of hematogones, and report recent advances in our understanding and knowledge of these cells as they relate to physiologic and different pathologic conditions.
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