Journal
LEUKEMIA & LYMPHOMA
Volume 49, Issue 6, Pages 1190-1201Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/10428190802064917
Keywords
lymphoma; Sezary syndrome; T-plastin; FoxP3; Mic-B; CD28; regulatory T-cell
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Funding
- NATIONAL CANCER INSTITUTE [P01CA015396, R01CA089194, P30CA006973] Funding Source: NIH RePORTER
- NCI NIH HHS [R01-CA89194, P01 CA015396, P30 CA006973, CA15396, R01 CA089194] Funding Source: Medline
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Peripheral blood cells from 28 patients with leukemic cutaneous T-cell lymphoma including 25 patients with Sezary syndrome were evaluated for expression of regulatory T-cell-associated markers (FoxP3, CD25, CTLA-4, neurophilin-1), T-cell activation markers (CD28 and its ligands B7.1 and B7.2) and NK cell-associated markers (NKG2D and its ligands Mic-A and Mic-B) using real-time quantitative polymerase chain reaction. T-plastin served as a positive genetic marker, and its expression correlated to blood tumor burden. More than 90% of samples had transcripts for CD28 and Mic-B, but less than 30% of samples expressed FoxP3, CTLA-4 and CD25. Expression of Mic-B by neoplastic cells could provide another mechanism to inhibit anti-tumor immune responses. FoxP3 expression correlated with a poor prognosis. Although the underlying mechanisms accounting for this correlation remain unclear, the expression of the Foxp3 and CTLA-4 regulatory elements indicates that a subset of leukemic cases displays a regulatory T-cell phenotype.
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