Journal
LEUKEMIA & LYMPHOMA
Volume 49, Issue 9, Pages 1668-1680Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/10428190802163339
Keywords
lymphoma and Hodgkin disease; prognostic markers; biomarkers; microenviroment; prognosis
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Classical Hodgkin lymphoma is now recognised as a B-cell lymphoma. Improved therapy has increased cure rates dramatically; however, relapse and death still occurs in a minority of patients. Much has been learned about the biology of Hodgkin and Reed Sternberg cells and their interactions with the microenvironment, which has informed studies exploring biologic markers that may improve upon clinical prognostic models. This manuscript reviews recent advances in our understanding of the pathobiology of cHL with an emphasis on biologic prognostic markers.
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