Journal
LEUKEMIA
Volume 25, Issue 7, Pages 1147-1152Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/leu.2011.71
Keywords
TET2; azacitidine; myelodysplastic syndromes; acute myeloid leukemia
Categories
Funding
- Celgene
Ask authors/readers for more resources
The impact of ten-eleven-translocation 2 (TET2) mutations on response to azacitidine (AZA) in MDS has not been reported. We sequenced the TET2 gene in 86 MDS and acute myeloid leukemia (AML) with 20-30% blasts treated by AZA, that is disease categories wherein this drug is approved by Food and Drug Administration (FDA). Thirteen patients (15%) carried TET2 mutations. Patients with mutated and wild-type (WT) TET2 had mostly comparable pretreatment characteristics, except for lower hemoglobin, better cytogenetic risk and longer MDS duration before AZA in TET2 mutated patients (P = 0.03, P = 0.047 and P = 0.048, respectively). The response rate (including hematological improvement) was 82% in MUT versus 45% in WT patients (P = 0.007). Mutated TET2 (P = 0.04) and favorable cytogenetic risk (intermediate risk: P = 0.04, poor risk: P = 0.048 compared with good risk) independently predicted a higher response rate. Response duration and overall survival were, however, comparable in the MUT and WT groups. In higher risk MDS and AML with low blast count, TET2 status may be a genetic predictor of response to AZA, independently of karyotype. Leukemia (2011) 25, 1147-1152; doi:10.1038/leu.2011.71; published online 15 April 2011
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available