Journal
LEUKEMIA
Volume 25, Issue 11, Pages 1674-1686Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/leu.2011.167
Keywords
stroke; cell therapy; migration; homing; neurogenesis; angiogenesis
Categories
Funding
- James and Esther King Foundation for Biomedical Research Program [1KG01-33966]
- NIH [R01 5R01NS071956-02]
- SanBio Inc.
- Celgene Cellular Therapeutics
- KMPHC
- Neural-Stem Inc.
- NINDS [UO1 5U01NS055914-04]
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Mobilizing bone cells to the head, astutely referred to as 'bonehead' therapeutic approach, represents a major discipline of regenerative medicine. The last decade has witnessed mounting evidence supporting the capacity of bone marrow (BM)-derived cells to mobilize from BM to peripheral blood (PB), eventually finding their way to the injured brain. This homing action is exemplified in BM stem cell mobilization following ischemic brain injury. Here, I review accumulating laboratory studies implicating the role of therapeutic mobilization of transplanted BM stem cells for brain plasticity and remodeling in stroke. Leukemia (2011) 25, 1674-1686; doi:10.1038/leu.2011.167; published online 5 July 2011
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