Journal
LEUKEMIA
Volume 25, Issue 10, Pages 1525-1532Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/leu.2011.127
Keywords
Notch; HSC; fetal hematopoiesis
Categories
Funding
- NIH
- Leukemia and Lymphoma Society
Ask authors/readers for more resources
Notch is a crucial cell signaling pathway in metazoan development. By means of cell-cell interactions, Notch signaling regulates cellular identity, proliferation, differentiation and apoptosis. Within the last decade, numerous studies have shown an important role for this pathway in the development and homeostasis of mammalian stem cell populations. Hematopoietic stem cells (HSCs) constitute a well-defined population that shows self-renewal and multi-lineage differentiation potential, with the clinically relevant capacity to repopulate the hematopoietic system of an adult organism. Here, we review the emergence, development and maintenance of HSCs during mammalian embryogenesis and adulthood, with respect to the role of Notch signaling in hematopoietic biology. Leukemia (2011) 25, 1525-1532; doi: 10.1038/leu.2011.127; published online 7 June 2011
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available