Journal
LEUKEMIA
Volume 26, Issue 5, Pages 1073-1080Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/leu.2011.263
Keywords
multiple myeloma; bone morphogenetic protein; MYC; apoptosis; oncogene addiction
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Funding
- Norwegian Microarray Consortium (NMC), Trondheim, Norway
- Norwegian Cancer Society
- Norwegian Research Council
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Bone morphogenetic proteins (BMPs) have been shown to induce apoptosis and growth arrest in myeloma cells. However, the molecular mechanisms behind these events are not known. The MYC oncogene is a master regulator of cell growth and protein synthesis and MYC overexpression has been proposed to be associated with the progression of multiple myeloma. Here, we show that BMP-induced apoptosis in myeloma cells is dependent on downregulation of MYC. Moreover, the results suggest that targeting the MYC addiction in multiple myeloma is an efficient way of killing a majority of primary myeloma clones. We also found that myeloma cells harboring immunoglobulin (IG)-MYC translocations evaded BMP-induced apoptosis, suggesting a novel way for myeloma cells to overcome potential tumor suppression by BMPs.
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