Journal
LEUKEMIA
Volume 25, Issue 9, Pages 1408-1414Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/leu.2011.108
Keywords
mesenchymal stromal cells; licensing; immune regulation
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Many in vitro and in vivo data are available supporting the role of mesenchymal stromal cell (MSC) licensing in the induction of a measurable and effective immune regulation. The failure of some MSC-based protocols for immune modulation in animal models and in human clinical trials may be explained by either lack of a proper licensing by inflammatory microenviroment or wrong timing in MSC administration. Thus, optimization of MSC use for immune-regulating purposes is required to maximize their beneficial effects. Leukemia (2011) 25, 1408-1414; doi: 10.1038/leu.2011.108; published online 27 May 2011
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