Journal
LEUKEMIA
Volume 25, Issue 6, Pages 979-984Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/leu.2011.49
Keywords
CLL; immunoglobulin; prognosis; IGHV; somatic mutation analysis
Categories
Funding
- Swedish Cancer Society
- Swedish Medical Research Council
- Associazione Italiana per la Ricerca sul Cancro Milano, Italy
- PRIN-MIUR, Rome, Italy
- CARIPLOFoundation, Milano, Italy
- Tenovus UK
- Tenovus Solentside
- Experimental Cancer Medicine Centre (ECMC) network
- French Ministry of Health
- ENosAI [09SYN-13-880]
- EU
- Hellenic General Secretariat for Research and Technology
- Greek Ministry of Health
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prognostication in chronic lymphocytic leukemia (CLL) and the definition of standardized procedures has allowed reliable and reproducible results. Occasionally, a straightforward interpretation of the sequences is not possible because of the so-called 'problematic sequences' that do not fit the 'classic' interpretation and pose scientific questions at the cross-road between hematology and immunology. Thanks to a dedicated effort within the European Research Initiative on CLL (ERIC), we have now the possibility to present such cases, offer a scientific explanation and propose recommendations in terms of prognostication. Leukemia (2011) 25, 979-984; doi:10.1038/leu.2011.49; published online 1 April 2011
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