4.7 Review

The role of PU.1 and GATA-1 transcription factors during normal and leukemogenic hematopoiesis

Journal

LEUKEMIA
Volume 24, Issue 7, Pages 1249-1257

Publisher

NATURE PUBLISHING GROUP
DOI: 10.1038/leu.2010.104

Keywords

PU.1; leukemia differentiation; GATA-1; chromatin; differentiation therapy

Funding

  1. Internal Grant Agency of Ministry of Health of the Czech Republic [NR9021-4/2006]
  2. Yorkshire Cancer Research
  3. Wellcome Trust

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Hematopoiesis is coordinated by a complex regulatory network of transcription factors and among them PU.1 (Spi1, Sfpi1) represents a key molecule. This review summarizes the indispensable requirement of PU.1 during hematopoietic cell fate decisions and how the function of PU.1 can be modulated by protein-protein interactions with additional factors. The mutual negative regulation between PU.1 and GATA-1 is detailed within the context of normal and leukemogenic hematopoiesis and the concept of 'differentiation therapy' to restore normal cellular differentiation of leukemic cells is discussed. Leukemia (2010) 24, 1249-1257; doi:10.1038/leu.2010.104; published online 3 June 2010

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