Journal
LEUKEMIA
Volume 24, Issue 7, Pages 1276-1282Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/leu.2010.102
Keywords
acute myeloid leukemia (AML); first complete remission; hematopoietic stem cell transplantation; unrelated donor; matched related donor
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Funding
- NIH [P01-CA18029, P01-AI33484, K08-CA95448, K23-CA137161, K99-HL088021]
- Frederick Kullman Memorial Fund
- Lymphoma Research Foundation
- Damon Runyon Cancer Foundation
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Hematopoietic cell transplantation (HCT) from a matched related donor (MRD) benefits many adults with acute myeloid leukemia (AML) in first complete remission (CR1). The majority of patients does not have such a donor and will require an alternative donor if HCT is to be undertaken. We retrospectively analyzed 226 adult AML CR1 patients undergoing myeloablative unrelated donor (URD) (10/10 match, n = 62; 9/10, n = 29) or MRD (n = 135) HCT from 1996 to 2007. The 5-year estimates of overall survival, relapse and nonrelapse mortality (NRM) were 57.9, 29.7 and 16.0%, respectively. Failure for each of these outcomes was slightly higher for 10/10 URD than MRD HCT, although statistical significance was not reached for any end point. The adjusted hazard ratios (HRs) were 1.43 (0.89-2.30, P = 0.14) for overall mortality, 1.17 (0.66-2.08, P = 0.60) for relapse and 1.79 (0.86-3.74, P = 0.12) for NRM, respectively, and the adjusted odds ratio for grades 2-4 acute graft-versus-host disease was 1.50 (0.70-3.24, P = 0.30). Overall mortality among 9/10 and 10/10 URD recipients was similar (adjusted HR 1.16 (0.52-2.61), P = 0.71). These data indicate that URD HCT can provide long-term survival for CR1 AML; outcomes for 10/10 URD HCT, and possibly 9/10 URD HCT, suggest that this modality should be considered in the absence of a suitable MRD. Leukemia (2010) 24, 1276-1282; doi:10.1038/leu.2010.102; published online 20 May 2010
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