Journal
LEUKEMIA
Volume 24, Issue 10, Pages 1667-1675Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/leu.2010.162
Keywords
S1P; SDF-1; CXCR4; stem cell mobilization; MAC
Categories
Funding
- NIH [R01 CA105847, R01 DK070577]
- European Union
- Innovative Economy Operational Program [POIG.01.01.01-00-109/09-01]
- Stella and Henry Endowment
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Hematopoietic stem and progenitor cells (HSPCs), as well as other types of stem cells, circulate under steady-state conditions at detectable levels in peripheral blood (PB), with their numbers increasing in response to stress, inflammation and tissue/organ injury. This mobilization process may be envisioned as a danger-sensing response mechanism triggered by hypoxia or mechanical or infection-induced tissue damage that recruits into PB different types of stem cells that have a role in immune surveillance and organ/tissue regeneration. Mobilization is also significantly enhanced by the administration of pharmacological agents, which has been exploited in hematological transplantology as a means to obtain HSPCs for hematopoietic reconstitution. In this review we will present mounting evidence that innate immunity orchestrates this evolutionarily conserved mechanism of HSPC mobilization. Leukemia (2010) 24, 1667-1675; doi:10.1038/leu.2010.162; published online 12 August 2010
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