4.2 Article

A Green Method for the Synthesis of 3-Substituted Coumarins Catalyzed by L-Lysine in Water Via Knoevenagel Condensation

Journal

LETTERS IN ORGANIC CHEMISTRY
Volume 9, Issue 1, Pages 19-23

Publisher

BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/157017812799303953

Keywords

Coumarins; green chemistry; knoevenagel condensation; L-lysine; water

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L-lysine was applied to the synthesis of 3-substituted coumarins through the condensation of various salicylaldehyde with reactive methylene compounds in water. In this work, waste minimization, catalyst recovery, simple operation and easier product work-up were achieved.

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