Synthesis of Vinylphosphonates and its First Exploration of Bioactivity

Phosphonation of beta-nitro-alkene with triethyl phosphite was achieved under microwave irradiation using CH2Cl (2) as the solvent in the absence of catalyst with moderate to high yields (up to 90%). This method of formation of carbon-phosphor bonds is simple, mild, convenient and effective. Synchronously, a number of vinylphosphonates derivatives were synthesized and evaluated biologically preliminary.