Journal
LETTERS IN ORGANIC CHEMISTRY
Volume 7, Issue 5, Pages 367-372Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/157017810791514652
Keywords
Organocatalyst; Michael addition; aromatic ketones; nitroolefins; primary-amine thiourea
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Funding
- National Natural Science Foundation of China [20802075]
- Chinese Academy of Sciences
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Simple chiral primary amine-thiourea catalysts derived from chiral 1,2-diphenylethylenediamine were found to catalyze direct Michael addition of aromatic ketones to nitroolefins with good enantioselectives (up to 86% ee) and excellent yields (up to 97%) for a broad range of substrates and successfully used in the preparation of (R)-Balcofen.
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