Journal
LETTERS IN ORGANIC CHEMISTRY
Volume 6, Issue 4, Pages 289-292Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/157017809788489828
Keywords
Lissoclimide; Haterumaimide; Diterpene; Alkaloid; Cytotoxicity; Aldol
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Funding
- Spanish Ministry of Science and Education, under a Ramon y Cajal
- Generalitat Valenciana [GV/2007/007]
- Antioquia University of Colombia and COLCIENCIAS, Bogota, Colombia [RC 432-2004]
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The first synthesis of lissoclimide-type alkaloids is described. Starting from commercial (+)-sclareolide, the aldehyde gamma-bicyclohomofarnesal is synthesized and coupled, through an aldol reaction, with succinimide. The antitumor activity of several lissoclimide analogues is also reported.
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