Journal
LETTERS IN ORGANIC CHEMISTRY
Volume 6, Issue 5, Pages 367-371Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/157017809788681428
Keywords
Azaphilones; bioconjugation; orthogonal reactivity; cross-linkage; fluorescent
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alpha-Bromoacetate esters of the azaphilone isochromene-6,8-dione core exhibit a pH-dependent orthogonal reactivity allowing for the one-pot cross-linkage of primary amines to thiols in an inter- or intramolecular fashion to afford fluorescent products. This represents a new potential strategy for bioconjugate chemistry.
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