Journal
LETTERS IN ORGANIC CHEMISTRY
Volume 5, Issue 2, Pages 142-147Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/157017808783743911
Keywords
Cyclocondensation multicomponent reaction; biginelli compounds; 3,4-dihydropyrimidin-2(1H)-ones and -thiones; ZrO2 nanopowder; environmentally benign; dry media
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A general and practical Green Chemistry route to the Biginelli cyclocondensation multicomponent reaction had been carried out by the three-component coupling of beta-ketoesters, various structurally diverse aldehydes including heterocyclic aldehydes and urea/thiourea in the presence of Zirconia (ZrO2) nanopowder catalyst in dry media under microwave irradiation and a comparative study was also done under thermal conditions giving 3,4-dihydropyrimidin-2(1H)-ones and -thiones (DHPMs) in excellent yields. Besides, it was highlighted that ZrO2 nanopowder can be reused up to six times after simple washing with ethyl acetate, thus exposing the process economical and environmentally benign.
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