4.2 Article

Synthesis and Antifungal Activity of 1,3,4-Thiadiazole Derivatives Containing Pyridine Group

Journal

LETTERS IN DRUG DESIGN & DISCOVERY
Volume 11, Issue 9, Pages 1107-1111

Publisher

BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1570180811666140610212731

Keywords

1,3,4-thiadiazole; antifungal activity; pyridine; synthesis

Funding

  1. National Natural Science Foundation of China [21002090]
  2. Key Innovation Team of Science and Technology in Zhejiang Province [2010R50018-06]
  3. National Key Technologies RD Program [2011BAE06B03-01]

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Some 1,3,4-thiadiazole derivatives containing pyridine group were synthesized. The structures of 1,3,4-thiadiazoles were confirmed by H-1 NMR, MS, and elemental analysis. The title compounds were investigated for antifungal activities. The results showed that some of them exhibited good antifungal activity.

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