Journal
LETTERS IN DRUG DESIGN & DISCOVERY
Volume 5, Issue 4, Pages 277-280Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/157018008784619843
Keywords
antimalarial; diaminopyrimidine; structure-activity relationship
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A series of 2,4- and 4,6-diaminopyrimidines were prepared and evaluated for their in vitro antimalarial activity. Of the 12 compounds tested 7 showed reasonable activity with 1 having a sub-micromolar IC50.
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