Journal
LETTERS IN DRUG DESIGN & DISCOVERY
Volume 5, Issue 8, Pages 485-488Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/157018008786898581
Keywords
Prostate cancer; 2-Chloro-1,4-naphthoquinone; Imides; Microwave-assisted synthesis
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Funding
- Howard University/Johns Hopkins Cancer Center Partnership [5-U54-CA914-31]
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The anticancer activities of six imido-substituted 2-chloro-1,4-naphthoquinone derivatives on one androgen-dependent, LNCaP, and two androgen-independent, PC3 and DU145, human prostate cancer cell lines are reported. The open chain imides (2-4) showed more potency in all three cell lines. In addition the microwave-assisted synthesis of five of these compounds is reported.
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