Journal
LEARNING & MEMORY
Volume 19, Issue 11, Pages 513-517Publisher
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/lm.026302.112
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Funding
- National Institute of Mental Health [R01MH068073, F32MH090750-01]
- National Institute of Mental Health Silvio O. Conte Center for Schizophrenia Research [MH086404]
- Lieber Institute for Brain Development
- Howard Hughes Medical Institute
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Working memory and attention are complex cognitive functions that are disrupted in several neuropsychiatric disorders. Mouse models of such human diseases are commonly subjected to maze-based tests that can neither distinguish between these cognitive functions nor isolate specific aspects of either function. Here, we have adapted a simple visual discrimination task, and by varying only the timing of events within the same task construct, we are able to measure independently the behavioral response to increasing attentional demand and increasing length of time that information must be maintained in working memory. We determined that mPFC lesions in mice impair attention but not working memory maintenance.
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