Journal
LEARNING & MEMORY
Volume 19, Issue 10, Pages 495-498Publisher
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/lm.026997.112
Keywords
-
Categories
Funding
- National Council for Scientific and Technological Development (CNPq) [303703/2009-1]
- National Institute for Translational Medicine (INCT-TM)
- Improvement of Higher Education Personnel (CAPES)
- HCPA Institutional Research Fund (FIPE/HCPA)
Ask authors/readers for more resources
Here we show that administration of the phosphodiesterase type 4 (PDE4) inhibitor rolipram into the basolateral complex of the amygdala (BLA) at a specific time interval after training enhances memory consolidation and induces memory persistence for novel object recognition (NOR) in rats. Intra-BLA infusion of rolipram immediately, 1.5 h, or 6 h after training had no effect on retention tested at 1, 7, and 14 d later. However, rolipram infused 3 h post-training promoted memory persistence for up to at least 14 d. The findings suggest that PDE4 inhibition in the BLA can enhance long-term memory formation when induced specifically 3 h after learning.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available