4.0 Article

The effect of D-cycloserine on immediate vs. delayed extinction of learned fear

Journal

LEARNING & MEMORY
Volume 17, Issue 11, Pages 547-551

Publisher

COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/lm.1927310

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Funding

  1. Australian Post-Graduate Award
  2. Australian Research Council [DP0985554]
  3. Australian Research Council [DP0985554] Funding Source: Australian Research Council

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We compared the effect of D-cycloserine (DCS) on immediate (10 min after conditioning) and delayed (24 h after conditioning) extinction of learned fear in rats. DCS facilitated both immediate and delayed extinction when the drug was administered after extinction training. However, DCS did not facilitate immediate extinction when administered prior to extinction training (i.e., when the interval between drug administration and shock was reduced). In addition, administering five, but not two, shocks prior to extinction training disrupted the facilitating effects of DCS on delayed extinction. These results suggest that aversive experiences prior to DCS administration can prevent it from facilitating extinction.

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