Journal
QUIMICA NOVA
Volume 38, Issue 5, Pages 605-608Publisher
SOC BRASILEIRA QUIMICA
DOI: 10.5935/0100-4042.20150045
Keywords
Sonogashira cross-coupling; Dupont's catalyst; experimental design
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Funding
- CNPq
- FAPERGS (Brazil)
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The optimisation of a new catalyst system using NCP pincer palladacycle 1 was investigated using the experimental design technique. NCP pincer palladacycle 1 was previously investigated in Suzuki-Miyaura and Heck-Mizoroki cross-couplings and found to be a highly efficient catalyst precursor. In this study, the effects of the type of base (K3PO4 or DABCO), solvent (DMF or dioxane) and reaction temperature (130 or 150 degrees C) in the second step on the reactional yield in Sonogashira cross-coupling were assessed using the two-factor design. The results showed that temperature is statistically significant in relation to the reaction yield.
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