4.3 Article

Biomedical properties of laser prepared silver-doped hydroxyapatite

Journal

LASER PHYSICS
Volume 21, Issue 7, Pages 1265-1269

Publisher

IOP PUBLISHING LTD
DOI: 10.1134/S1054660X11130159

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Funding

  1. Ministry of Education, Youth and Sports of the Czech Republic [MSM6840770012]
  2. Institutional Research Plan AVOZ [10100522]
  3. Grant agency of CTU [OHK4-036/10]
  4. Grant Agency of the Czech Republic [204/07/0325]

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Thin films of hydroxyapatite (HA) and silver-doped HA were synthesized using KrF excimer laser deposition. Material was ablated from one target composed from silver and HA segments. Layers properties as silver content, structure, color, FTIR spectra and antibacterial properties (Gram-positive Bacillus subtilis) were measured. Silver concentration in HA layers of 0.06, 0.3, 1.2, 4.4, 8.3, and 13.7 at % was detected. The antibacterial efficacy changed with silver dopation from 71.0 to 99.9%. The focus is on investigation of minimum Ag concentration needed to reach a high antibacterial efficacy.

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