Journal
LARYNGOSCOPE
Volume 129, Issue 3, Pages 709-714Publisher
WILEY
DOI: 10.1002/lary.27502
Keywords
Laryngopharyngeal reflux; pepsin; proton pump inhibitor; saliva; sputum
Funding
- Ministry of Science and Technology, Taiwan [NSC101-2314-B-075A-004-MY3]
Ask authors/readers for more resources
Objectives/Hypothesis To evaluate the prediction value of saliva pepsin detection for an 8-week proton pump inhibitor (PPI) response in patients with a Reflux Symptoms Index (RSI) score >= 13, which indicates possible laryngopharyngeal reflux. Study Design Prospective individual single-cohort study. Methods Patients were recruited who had experienced chronic laryngopharyngeal symptoms (RSI score >= 13) for more than 3 months after excluding other etiologies. The patients received PPI (40 mg of esomeprazole once daily) treatment for 8 weeks. Prior to treatment, the patients submitted saliva/sputum samples that were collected during the time symptoms were observed. The samples were taken for pepsin detection, and performed using the commercially available Peptest lateral flow device. The association of the Peptest results and PPI response were statistically analyzed with the chi(2) test. Results Seventy-four patients completed the study, and upon completion of PPI treatment, the mean RSI score was significantly reduced from 19.22 +/- 5.18 to 8.99 +/- 5.69. Forty-four (59.5%) patients exhibited a good response as defined by an RSI score reduction >= 50%. The results of the Peptest were semiquantitatively graded as 0, 1, 2, 3 (negative, weak positive, moderate positive and strong positive, respectively) based upon the visual intensity of the test sample line as compared to the control line. Twenty-four patients (32.4%) exhibited grade 3 strong positive results. The Peptest strong positive results (P < .05) were significantly associated with a good PPI response, with the positive predictive value being 79.2%. Conclusions Analysis of strong positive results for pepsin detection in saliva/sputum samples may be a useful, noninvasive method for predicting better PPI response in patients with suspected reflux induced chronic laryngopharyngeal
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available