Journal
LARYNGOSCOPE
Volume 121, Issue 1, Pages 102-105Publisher
WILEY
DOI: 10.1002/lary.21165
Keywords
Gastroesophageal reflux disease; extraesophageal reflux; laryngeal cancer; reverse causality
Funding
- U.S. Department of Veterans Affairs Northwest Center of Excellence for Health Services Research and Development
- American Academy of Otolaryngology-Head and Neck Surgery Resident Research C.O.R.E.
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Objectives/Hypothesis: The relationship between gastroesophageal reflux disease (GERD) and laryngeal cancer has not been fully elucidated. This case-control study investigates whether GERD increases the odds of developing these malignancies. Study Design: Case-control study. Methods: Rates of GERD among cases of laryngeal cancer identified in the Veterans Health Administration outpatient care files (year 2000-2006) were compared with controls. Cases (N = 14,449) were frequency matched 1:1 with controls. Multivariate logistic regression was used to determine the association between GERD and cancer. Results: After adjusting for tobacco and/or alcohol use, there was no association between GERD and laryngeal cancer (adjusted odds ratio, 1.01; 95% confidence interval, 0.92-1.12, P =.780). Although an association was found when time from GERD diagnosis to malignancy was less than 3 months, it disappeared when this period was extended further. Conclusions: In this population, there was no increased risk of laryngeal cancer among patients with GERD. However, in subsite analysis, a possible relationship between GERD and glottic cancer was observed. Reverse causality must be considered in future studies assessing the relationship between reflux and laryngeal cancer to limit misclassification bias.
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