Journal
LANGMUIR
Volume 34, Issue 36, Pages 10721-10731Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.langmuir.8b01516
Keywords
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Funding
- Natural Science Foundation of China [21303014]
- Swiss National Science Foundation [200020_165917]
- State Key Laboratory of Molecular Engineering of Polymers (Fudan University)
- Key Laboratory of Science & Technology of Eco-Textiles of the Ministry of Education
- Fundamental Research Funds for the Central Universities
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Glycopolymers with large galactose units are attractive in biological processes because of their ability to selectively recognize lectin proteins. Recently, thermoresponsive double-hydrophilic block glycopolymers (TDHBGs) have been designed, which allow sugar residues to expose or hide via the lower critical solution temperature (LCST)-type phase transition. In this work, we first synthesize a new type of TDHBGs, composed of a thermoresponsive poly(di(ethylene glycol)methyl ether methacrylate) block and a galactose-functionalized, poly(6-O-vinyladipoyl-D-galactose) (POVNG) block. The LCST can be tuned by varying the size of the POVNG block. Then, we have systematically investigated their thermoresponsive self-assembly behavior, using static and dynamic light scattering techniques, combined with transmission electron microscopy (TEM) imaging. It is found that the TDHBGs possess both micellization and LCST-type transition, and there exist strong interactions between them, depending on the concentration and structure of the TDHBGs. It is particularly interesting that for the same type of TDHBGs under different conditions, such interactions result in rich morphologies of the formed micelles (or nanoparticles) such as spheres, hollow spheres, prolate ellipsoids, crystal-like, and so on, thus potentially enriching their biological applications by noting that they are hepatoma-targeting glycopolymers.
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