Journal
LANGMUIR
Volume 30, Issue 41, Pages 12114-12118Publisher
AMER CHEMICAL SOC
DOI: 10.1021/la503075e
Keywords
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Funding
- National Science Foundation [CHE-1145500]
- National Institutes of Health [HL67773, 5 T32 HL00725]
- North Carolina Biotechnology Center [2009-IDG-1031]
- Division Of Chemistry
- Direct For Mathematical & Physical Scien [1145500] Funding Source: National Science Foundation
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One of the long-standing issues surrounding cholesterol (Chol) relates to its two-faced character. In particular, the consequences of its having a rough beta-face and a smooth alpha-face on its structural influence in cell membranes has remained elusive. In this study, direct comparisons have been made between cholesterol and a smoothened analog, DChol (i.e., 18,19-dinorcholesterol) using model membranes and a combination of nearest-neighbor recognition, differential scanning calorimetry, fluorescence, and monolayer measurements. Taken together, these results indicate that subtle differences exist between the interaction of these two sterols with the different states of 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC). Chol has a greater condensing power than DChol, but only slightly so, i.e., on the order of a few tens of calories per mole.
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