Journal
LANGMUIR
Volume 30, Issue 44, Pages 13125-13136Publisher
AMER CHEMICAL SOC
DOI: 10.1021/la5035382
Keywords
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Funding
- Institute of Bioengineering and Nanotechnology (Biomedical Research Council, Agency for Science, Technology, and Research, Singapore)
- France-Singapore Merlion Program [8.02.10]
- CNRS through the Interface Physique, Chimie, Biologie program
- [O2.1.2]
- [209]
- [665]
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This paper presents a microfluidic method for precise control of the size and polydispersity of surfactantDNA nanoparticles. A mixture of surfactant and DNA dispersed in 35% ethanol is focused between two streams of pure water in a microfluidic channel. As a result, a rapid change of solvent quality takes place in the central stream, and the surfactant-bound DNA molecules undergo a fast coilglobule transition. By adjusting the concentrations of DNA and surfactant, fine-tuning of the nanoparticle size, down to a hydrodynamic diameter of 70 nm with a polydispersity index below 0.2, can be achieved with a good reproducibility.
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