Journal
LANGMUIR
Volume 30, Issue 6, Pages 1580-1587Publisher
AMER CHEMICAL SOC
DOI: 10.1021/la403591z
Keywords
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Funding
- NSF [DMR-0805179]
- NSF Materials World Network program [DMR-0909065]
- Institute for Critical Technologies and Applied Sciences at Virginia Tech
- Division Of Materials Research
- Direct For Mathematical & Physical Scien [1106182] Funding Source: National Science Foundation
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We report the fabrication of magnetic particles comprised of clusters of iron oxide nanoparticles, 7.4 nm mean diameter, stabilized by a biocompatible, amphiphilic diblock copolymer, poly(ethylene oxide-b-D,L-lactide). Particles with quantitative incorporation of up to 40 wt % iron oxide and hydrodynamic sizes in the range of 80-170 nm were prepared. The particles consist of hydrophobically modified iron oxide nanoparticles within the core-forming polylactide block with the poly(ethylene oxide) forming a corona to afford aqueous dispersibility. The transverse relaxivities (r(2)) increased with average particle size and exceeded 200 s(-1) mM Fe-1 at 1.4 T and 37 degrees C for iron oxide loadings above 30 wt %. These experimental relaxivities typically agreed to within 15% with the values predicted using analytical models of transverse relaxivity and cluster (particle core) size distributions derived from cryo-TEM measurements. Our results show that the theoretical models can be used for the rational design of biocompatible MRI contrast agents with tailored compositions and size distributions.
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