Journal
LANGMUIR
Volume 29, Issue 16, Pages 5050-5059Publisher
AMER CHEMICAL SOC
DOI: 10.1021/la400163q
Keywords
-
Funding
- EPSRC [EP/F048114/1, EP/G026203/1]
- [SC3468]
- EPSRC [EP/G067538/1, EP/G026203/1, EP/F048114/1] Funding Source: UKRI
- Engineering and Physical Sciences Research Council [EP/G067538/1, EP/G026203/1, EP/F048114/1] Funding Source: researchfish
Ask authors/readers for more resources
The self-assembly in water of designed peptide amphiphile (PA) C-16-ETTES containing two anionic residues and its mixtures with C-16-KTTKS containing two cationic residues has been investigated Multiple spectroscopy, microscopy, and scattering techniques are used to examine ordering extending from the beta-sheet structures up to the fibrillar aggregate structure. The peptide amphiphiles both comprise a hexadecyl alkyl chain and a charged pentapeptide headgroup containing two charged residues. For C-16-ETTES, the critical aggregation concentration was determined by fluorescence experiments. FTIR and CD spectroscopy were used to examine beta-sheet formation. TEM revealed highly extended tape nanostructures with some striped regions corresponding to bilayer structures viewed edge-on. Small-angle X-ray scattering showed a main 5.3 nm bilayer spacing along with a 3 nm spacing. These spacings are assigned respectively to predominant hydrated bilayers and a fraction of dehydrated bilayers. Signs of cooperative self-assembly are observed in the mixtures, including reduced bundling of peptide amphiphile aggregates (extended tape structures) and enhanced beta-sheet formation.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available