Journal
LANGMUIR
Volume 29, Issue 38, Pages 11975-11981Publisher
AMER CHEMICAL SOC
DOI: 10.1021/la402589j
Keywords
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Funding
- TTI
- Strategic Research Infrastructure Project of the Ministry of Education, Sports, Science and Technology, Japan
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The hydroxyapatite (HA) formation on the DNA molecules in SBF was examined. After immersion for four weeks in SBF at 36.5 degrees C, the HA crystallites of similar to 1-14 mu m in diameter grew on the surface of DNA molecules. Various morphologies were successfully observed through scanning electron microscopy analysis. The Ca/P mol ratio (1.1-1.5) in HA was estimated by energy dispersive X-ray analysis. Original peaks of both of DNA and HA were characterized by Fourier transform infrared spectroscopy. The molecular orbital computer simulation has been used to probe the interaction of DNA with two charge-balancing ions, i.e., CaOH+ and CaH2PO4+. The adsorption enthalpy of the two ions on ds-DNA and/or ss-DNA having large negative value (similar to -60 kcal/mol per charge-balancing ion) was the evidence for the interface in mineralization of HA in SBF.
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