Journal
LANGMUIR
Volume 28, Issue 19, Pages 7551-7556Publisher
AMER CHEMICAL SOC
DOI: 10.1021/la300863d
Keywords
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Funding
- Priority Research Centers Program [2011-0030744]
- Basic Science Research Program [2010-0008116]
- Institute of Biological Engineering of Seoul National University
- Global Ph.D. Fellowship Program [2011-0007317]
- National Research Foundation of Korea (NRF)
- Technology Development Program [110031-3]
- Technology Development Program for Agriculture and Forestry and Animal, Plant and Fisheries Quarantine and Inspection Agency [Z-AD14-2011-12-02, I-AD14-2011-13-11]
- Ministry for Food, Agriculture, Forestry and Fisheries, Korea
- National Science Foundation, USA [0644864]
- Direct For Mathematical & Physical Scien
- Division Of Materials Research [0644864] Funding Source: National Science Foundation
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We present polydiacetylene (PDA) liposome assemblies with various phospholipids that have different head-group charges and phase transition temperatures (T-m). 10,12-Pentacosadiynoic acid (PCDA)-epoxy was used as a base PDA monomer and the insertion of highly charged phospholipids resulted in notable changes in the size of Liposome and reduction of the aggregation of PDA liposome. Among the various phospholipids, the phospholipid with a moderate T-m demonstrated enhanced stability and sensitivity, as measured by the size and zeta potential over storage time, thermochoromic response, and transmission electron microscopy images. By combining these results, we were able to detect immunologically an antibody of bovine viral diarrhea virus over a wide dynamic range of 0.001 to 100 mu g/mL.
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