Journal
LANGMUIR
Volume 28, Issue 41, Pages 14562-14566Publisher
AMER CHEMICAL SOC
DOI: 10.1021/la303271f
Keywords
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Funding
- National Basic Research Program of China [2013CB834502]
- NSFC [20974059]
- Foundation for Innovative Research Groups of the NSFC [21121004]
- NSFC-DFG [TRR 61]
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Chitosan and adenosine-5'-triphosphate (ATP) are employed as building blocks to fabricate polymeric supra-amphiphiles based on electrostatic interactions, which can self-assemble to form spherical aggregates. The spherical aggregates inherit the phosphotase responsiveness of ATP. Compared to our previous work, this enzyme-responsive system can be more biocompatible and block polymers are not needed in preparation, which makes it possible to fabricate the chitosan-based enzyme-responsive assemblies in a large-scale, cheap way. Therefore, the application of the assemblies for nanocontainers and drug delivery is greatly anticipated.
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