Journal
LANGMUIR
Volume 28, Issue 23, Pages 8589-8593Publisher
AMER CHEMICAL SOC
DOI: 10.1021/la300268d
Keywords
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Funding
- NSF-Biomaterials [DMR-0706655]
- MRSEC at GEMSEC, Genetically Engineered Materials Science and Engineering Center, University of Washington [DMR-0520567]
- NSF
- NCI [T32CA138312]
- JST PRESTO (Japan)
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The systematic control over surface chemistry is a long-standing challenge in biomedical and nanotechnological applications for graphitic materials. As a novel approach, we utilize graphite-binding dodecapeptides that self-assemble into dense domains to form monolayer-thick long-range-ordered films on graphite. Specifically, the peptides are rationally designed through their amino acid sequences to predictably display hydrophilic and hydrophobic characteristics while maintaining their self-assembly capabilities on the solid substrate. The peptides are observed to maintain a high tolerance for sequence modification, allowing control over surface chemistry via their amino acid sequence. Furthermore, through a single-step coassembly of two differently designed peptides, we predictably and precisely tune the wettability of the resulting functionalized graphite surfaces from 44 degrees to 83 degrees. The modular molecular structures and predictable behavior of short peptides demonstrated here give rise to a novel platform for functionalizing graphitic materials that offers numerous advantages, including noninvasive modification of the substrate, biocompatible processing in an aqueous environment, and simple fusion with other functional biological molecules.
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