Journal
LANGMUIR
Volume 28, Issue 51, Pages 17733-17742Publisher
AMER CHEMICAL SOC
DOI: 10.1021/la3036902
Keywords
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Funding
- Center-of-Excellence (COE) Program on Membrane Technology from the Ministry of Education (MOE), R.O.C.
- Outstanding Professor Research Program in the Chung Yuan Christian University, Taiwan [CYCU-107090022]
- National Science Council [NSC 101-2622-E-033-006-CC1, NSC 101-3011-P-033-004]
- Grants-in-Aid for Scientific Research [24560968] Funding Source: KAKEN
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In this work, the hemocompatibility of zwitterionic polypropylene (PP) fibrous membranes with varying grafting coverage of poly(sulfobetaine methacrylate) (PSBMA) via plasma-induced surface polymerization was studied. Charge neutrality of PSBMA-grafted layers on PP membrane surfaces was controlled by the low-pressure and atmospheric plasma treatment in this study. The effects of grafting composition, surface hydrophilicity, and hydration capability on blood compatibility of the membranes were determined. Protein adsorption onto the different PSBMA-grafted PP membranes from human fibrinogen solutions was measured by enzyme-linked immunosorbent assay (ELISA) with monoclonal antibodies. Blood platelet adhesion and plasma clotting time measurements from a recalcified platelet-rich plasma solution were used to determine if platelet activation depends on the charge bias of the grafted PSBMA layer. The charge bias of PSBMA layer deviated from the electrical balance of positively and negatively charged moieties can be well-controlled via atmospheric plasma-induced interfacial zwitterionization and was further tested with human whole blood. The optimized PSBMA surface graft layer in overall charge neutrality has a high hydration capability and keeps its original blood-inert property of antifouling, anticoagulant, and antithrmbogenic activities when it comes into contact with human blood. This work suggests that the hemocompatible nature of grafted PSBMA polymers by controlling grafting quality via atmospheric plasma treatment gives a great potential in the surface zwitterionization of hydrophobic membranes for use in human whole blood.
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