Journal
LANGMUIR
Volume 28, Issue 31, Pages 11625-11632Publisher
AMER CHEMICAL SOC
DOI: 10.1021/la302433a
Keywords
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Funding
- Office of Naval Research [N000140910137]
- National Cancer Institute [U54 CA119335-04S1]
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Nonionic polyethylene glycol (PEG) as a stealth polymer destabilizes liposomes due to its amphiphilic property. As a result, PEGylated liposomes have to be further stabilized, such as by using a large amount cholesterol. This is a long existing dilemma faced by PEG. In this work, we show that zwitterionic poly(carboxybetaine) (PCB) stabilizes liposomes because of its superhydrophilic nature, thus solving this dilemma, Specifically, PCB-modified liposomes without cholesterol exhibited good retention of hydrophilic drug and long blood circulating characteristics in vivo. To further validate this new PCB chemistry, PCB liposomal doxorubicin without cholesterol was compared with DOXIL for their antitumor therapeutic efficacies.
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