Journal
LANGMUIR
Volume 27, Issue 10, Pages 5874-5878Publisher
AMER CHEMICAL SOC
DOI: 10.1021/la2009682
Keywords
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Funding
- National Basic Research Program [2007CB808000]
- National Natural Science Foundation of China [21074066, 50973051, 20974059]
- Tsinghua University [2009THZ02-2]
- National Science Foundation of China (NSFC)-German Research Foundation (DFG) [TRR 61]
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We have developed a potential radiation-sensitive drug-delivery system using active diselenide-containing block co-polymer aggregates in aqueous solution that can load and release anticancer drugs. These aggregates were sensitive to even a low dose of gamma-radiation, such as 5 Gy, which is close to the radiation dose received by patients during a single radiotherapy treatment. This line of research may open an avenue for the combination of radiotherapy and chemotherapy.
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