Journal
LANGMUIR
Volume 27, Issue 15, Pages 9165-9173Publisher
AMER CHEMICAL SOC
DOI: 10.1021/la201200r
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Funding
- Fondazione Cariplo
- University of Pavia
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In the present work, we describe a simple procedure to produce biomimetically coated silver nanopartides (Ag NPs), based on the postfunctionalization and purification of colloidal silver stabilized by citrate. Two biological capping agents have been used (cysteine Cys and glutathione GSH). The composition of the capped colloids has been ascertained by different techniques and antibacterial tests on GSH-capped Ag NPs have been conducted under physiological conditions, obtaining values of Minimum Inhibitory Concentration (MIC) of 180 and 15 mu g/mL for Staphylococcus aureus and Escherichia coli, respectively. The antibacterial activity of these GSH capped NPs can be ascribed to the direct action of metallic silver NPs, rather than to the bulk release of Ag+.
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