4.6 Article

Photopatterning of Cell-Adhesive-Modified Poly(ethyleneimine) for Guided Neuronal Growth

Journal

LANGMUIR
Volume 27, Issue 6, Pages 2717-2722

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/la103372v

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Funding

  1. Ministry of Education, Science and Technology [2009-00503(10SF1510)]
  2. Electronics and Telecommunications Research Institute [11ZC1130]

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We describe photopatterning technique that employs the photodegradation of cell-adhesive-modified poly(ethyleneimine) (rn-PEI) to fabricate precise micropatterns on the indium tin oxide (ITO) substrate for guided neuronal growth. The photodegradation of m-PEI coated on hydroxyl group-terminated ITO substrate created micropatterns over a large area through deep UV irradiation. The photopatterned m-PEI layer can effectively guide neurite out-growth and control neurite extensions from individual neurons.

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