Journal
LANGMUIR
Volume 27, Issue 8, Pages 5147-5156Publisher
AMER CHEMICAL SOC
DOI: 10.1021/la104400m
Keywords
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Funding
- National Basic Research Program of China [2007CB714507, 2011CB933600]
- Science Fund for Creative Research Groups [20921062]
- National Natural Science Foundation of China [20875072]
- Ministry of Public Health [2009ZX10004-107, 2008-ZX10004-004]
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As is well known, controlling the local magnetic field distribution on the micrometer scale in a microfluidic chip is significant and has many applications in bioanalysis based on magnetic beads. However, it is a challenge to tailor the magnetic field introduced by external permanent magnets or electromagnets on the micrometer scale. Here, we demonstrated a simple approach to controlling the local magnetic field distribution on the micrometer scale in a microfluidic chip by nickel patterns encapsulated in a thin poly(dimethylsiloxane) (PDMS) film under the fluid channel. With the precisely controlled magnetic field, magnetic bead patterns were convenient to generate. Moreover, two kinds of fluorescent magnetic beads were patterned in the microfluidic channel, which demonstrated that it was possible to generate different functional magnetic bead Patterns in situ, and could be used for the detection of multiple targets. In addition, this method was applied to generate cancer cell patterns.
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